Oprah Winfrey, 71, is once again bringing the challenge of losing weight sustainably and without stigma to the forefront of the conversation. The iconic American television host, author of the book “Enough: Your Health, Your Weight and What It's Like to Be Free,” spoke candidly about her personal experience with obesity medications, the emotional ups and downs, and the impact of letting go of unrealistic expectations about the human body. Winfrey co-wrote the book “Enough” with Dr. Ania Jastreboff about her weight loss journey. In a recent promotional interview, she recounted how years ago she decided to discontinue her treatment with GLP-1 medications—a class of drugs originally developed for diabetes that are now used to control appetite and weight—to see if she could maintain the results with diet and exercise alone. The result was clear: the “mental noise” about food returned, and with it, the extra weight. “I tried to maintain my weight with just diet and exercise, but the noise in my head came back, and so did the weight,” the host admitted. This “noise” isn't just an expression: Oprah describes it as a constant struggle with obsessive thoughts about eating, something these medications help to alleviate by modifying the hunger signals that reach the brain. Several experts and testimonials agree that, after discontinuing this type of treatment, it's common to regain weight because the biological mechanisms that drive hunger don't disappear completely. Between pain, shame, and guilt, Winfrey not only spoke about the relapse but also about the public pressure she has experienced for decades. Her weight was the subject of persistent media coverage and, in some cases, open ridicule, something she herself accepted as part of her own process of self-blame. She recalled painful moments, such as when a public figure ridiculed her for her weight gain at the beginning of her career, reinforcing the idea that her struggle was a personal failure. At her peak weight, Oprah reached a weight of nearly 238 lbs (107 kg), but after the controversial medication regimen, she lost approximately 49 lbs (22 kg).“I went off medication all last year and gained 20 pounds because I wanted to try it,” she confided in an interview. "Because everyone was saying, 'You're going to gain weight… I'm going to prove them wrong; I'm going to make a difference.' And so, I was taking them, then I stopped, and I gained three pounds, and five pounds, and I gained ten pounds, and before I knew it, the food cravings were back.” “It's not simply a matter of willpower.” Today, with perspective and science, Oprah emphasizes that obesity is a complex medical condition, not simply a matter of willpower. This understanding led her to try modern therapies that have helped stabilize her relationship with food and her overall well-being. The presenter now sees these treatments as tools, not shortcuts, and warns against the risks of idealizing easy solutions while emphasizing the importance of professional support and health education. In her book and public statements, Winfrey blends personal stories with up-to-date medical information to combat the stigma faced by millions. “I want people to know it's not your fault,” she has said on several occasions, seeking to change the narrative around weight, health, and self-compassion. You may also be interested in: Oprah Winfrey shocks with her weight loss and shares details. Why do some bodies struggle to lose weight more than others? Where to get a free flu shot in the US and why it's crucial this year. In her book and public statements, Winfrey blends personal stories with up-to-date medical information to combat the stigma faced by millions. “I want people to know it's not your fault,” she has said on several occasions, seeking to change the narrative surrounding weight, health, and self-compassion. You may also be interested in: Oprah Winfrey shocks with her weight loss and shares details. Why do some bodies struggle to lose weight more than others? Where to get a free flu shot in the US and why it's crucial this year. In her book and public statements, Winfrey blends personal stories with up-to-date medical information to combat the stigma faced by millions. “I want people to know it's not your fault,” she has said on several occasions, seeking to change the narrative surrounding weight, health, and self-compassion. You may also be interested in: Oprah Winfrey shocks with her weight loss and shares details. Why do some bodies struggle to lose weight more than others? Where to get a free flu shot in the US and why it's crucial this year.Oprah emphasizes that obesity is a complex medical condition, not simply a matter of willpower. This understanding led her to try modern therapies that have helped stabilize her relationship with food and her overall well-being. The presenter now sees these treatments as tools, not shortcuts, and warns against the risks of idealizing easy solutions while emphasizing the importance of professional support and health education. In her book and public statements, Winfrey blends personal stories with up-to-date medical information to combat the stigma faced by millions. “I want people to know it's not your fault,” she has said on several occasions, seeking to change the narrative around weight, health, and self-compassion. You may also be interested in: Oprah Winfrey shocks with her weight loss and shares details. Why do some bodies struggle to lose weight more than others? Where to get a free flu shot in the US and why it's crucial this year. In her book and public statements, Winfrey blends personal stories with up-to-date medical information to combat the stigma faced by millions. “I want people to know it's not your fault,” she has said on several occasions, seeking to change the narrative surrounding weight, health, and self-compassion. You may also be interested in: Oprah Winfrey shocks with her weight loss and shares details. Why do some bodies struggle to lose weight more than others? Where to get a free flu shot in the US and why it's crucial this year. In her book and public statements, Winfrey blends personal stories with up-to-date medical information to combat the stigma faced by millions. “I want people to know it's not your fault,” she has said on several occasions, seeking to change the narrative surrounding weight, health, and self-compassion. You may also be interested in: Oprah Winfrey shocks with her weight loss and shares details. Why do some bodies struggle to lose weight more than others? Where to get a free flu shot in the US and why it's crucial this year.Oprah emphasizes that obesity is a complex medical condition, not simply a matter of willpower. This understanding led her to try modern therapies that have helped stabilize her relationship with food and her overall well-being. The presenter now sees these treatments as tools, not shortcuts, and warns against the risks of idealizing easy solutions while emphasizing the importance of professional support and health education. In her book and public statements, Winfrey blends personal stories with up-to-date medical information to combat the stigma faced by millions. “I want people to know it's not your fault,” she has said on several occasions, seeking to change the narrative around weight, health, and self-compassion. You may also be interested in: Oprah Winfrey shocks with her weight loss and shares details. Why do some bodies struggle to lose weight more than others? Where to get a free flu shot in the US and why it's crucial this year. In her book and public statements, Winfrey blends personal stories with up-to-date medical information to combat the stigma faced by millions. “I want people to know it's not your fault,” she has said on several occasions, seeking to change the narrative surrounding weight, health, and self-compassion. You may also be interested in: Oprah Winfrey shocks with her weight loss and shares details. Why do some bodies struggle to lose weight more than others? Where to get a free flu shot in the US and why it's crucial this year. In her book and public statements, Winfrey blends personal stories with up-to-date medical information to combat the stigma faced by millions. “I want people to know it's not your fault,” she has said on several occasions, seeking to change the narrative surrounding weight, health, and self-compassion. You may also be interested in: Oprah Winfrey shocks with her weight loss and shares details. Why do some bodies struggle to lose weight more than others? Where to get a free flu shot in the US and why it's crucial this year.In her book and public statements, Winfrey blends personal stories with up-to-date medical information to combat the stigma faced by millions. “I want people to know it's not your fault,” she has said on several occasions, seeking to change the narrative surrounding weight, health, and self-compassion. You may also be interested in: Oprah Winfrey shocks with her weight loss and shares details. Why do some bodies struggle to lose weight more than others? Where to get a free flu shot in the US and why it's crucial this year. In her book and public statements, Winfrey blends personal stories with up-to-date medical information to combat the stigma faced by millions. “I want people to know it's not your fault,” she has said on several occasions, seeking to change the narrative surrounding weight, health, and self-compassion. You may also be interested in: Oprah Winfrey shocks with her weight loss and shares details. Why do some bodies struggle to lose weight more than others? Where to get a free flu shot in the US and why it's crucial this year.In her book and public statements, Winfrey blends personal stories with up-to-date medical information to combat the stigma faced by millions. “I want people to know it's not your fault,” she has said on several occasions, seeking to change the narrative surrounding weight, health, and self-compassion. You may also be interested in: Oprah Winfrey shocks with her weight loss and shares details. Why do some bodies struggle to lose weight more than others? Where to get a free flu shot in the US and why it's crucial this year. In her book and public statements, Winfrey blends personal stories with up-to-date medical information to combat the stigma faced by millions. “I want people to know it's not your fault,” she has said on several occasions, seeking to change the narrative surrounding weight, health, and self-compassion. You may also be interested in: Oprah Winfrey shocks with her weight loss and shares details. Why do some bodies struggle to lose weight more than others? Where to get a free flu shot in the US and why it's crucial this year.